Drug interactions
Isoflurane + Lapatinib
Severity: Moderate
Isoflurane and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can prolong the QT interval and isoflurane can add to this effect. The combination raises arrhythmia risk, especially with electrolyte disturbances.
What this interaction means in plain words
Isoflurane and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Check baseline QTc and correct potassium and magnesium before surgery. Monitor the ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Isoflurane with Lapatinib?
MediHelp rates the interaction as moderate. Isoflurane and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib can prolong the QT interval and isoflurane can add to this effect. The combination raises arrhythmia risk, especially with electrolyte disturbances.
How serious is the interaction between Isoflurane and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and correct potassium and magnesium before surgery. Monitor the ECG during anesthesia.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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