Drug interactions
Isoflurane + Maprotiline
Severity: Moderate
Isoflurane and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval and, together with maprotiline, may increase the risk of arrhythmias and hypotension during anesthesia.
What this interaction means in plain words
Isoflurane and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization and autonomic cardiovascular regulation.
What to do
Tell the anesthesiologist about maprotiline and obtain a preoperative ECG. Correct electrolytes and monitor the ECG and blood pressure during the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Maprotiline?
MediHelp rates the interaction as moderate. Isoflurane and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval and, together with maprotiline, may increase the risk of arrhythmias and hypotension during anesthesia.
How serious is the interaction between Isoflurane and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesiologist about maprotiline and obtain a preoperative ECG. Correct electrolytes and monitor the ECG and blood pressure during the procedure.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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