Drug interactions
Isoflurane + Methohexital
Severity: Moderate
Isoflurane and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate induction agent commonly followed by isoflurane maintenance. The two add together to produce deeper sedation, hypotension and respiratory depression.
What this interaction means in plain words
Isoflurane and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through enhancement of GABA-A receptor activity.
What to do
Titrate each agent to effect and lower the isoflurane requirement after methohexital induction. Monitor blood pressure, ventilation and oxygenation continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Methohexital
Frequently asked questions
Can I take Isoflurane with Methohexital?
MediHelp rates the interaction as moderate. Isoflurane and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate induction agent commonly followed by isoflurane maintenance. The two add together to produce deeper sedation, hypotension and respiratory depression.
How serious is the interaction between Isoflurane and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate each agent to effect and lower the isoflurane requirement after methohexital induction. Monitor blood pressure, ventilation and oxygenation continuously.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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