Drug interactions
Isoflurane + Mifepristone
Severity: Moderate
Isoflurane and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, at the higher doses used for Cushing syndrome, prolongs the QT interval. Isoflurane may add to this and raise torsades risk.
What this interaction means in plain words
Isoflurane and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Check baseline QTc and correct hypokalemia, which is common in Cushing syndrome. Monitor the ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Isoflurane with Mifepristone?
MediHelp rates the interaction as moderate. Isoflurane and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone, at the higher doses used for Cushing syndrome, prolongs the QT interval. Isoflurane may add to this and raise torsades risk.
How serious is the interaction between Isoflurane and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and correct hypokalemia, which is common in Cushing syndrome. Monitor the ECG during anesthesia.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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