Drug interactions
Isoflurane + Primaquine
Severity: Moderate
Isoflurane and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval and primaquine may add to this effect. The risk is greatest during surgery when electrolyte disturbances and other QT-active drugs are common.
What this interaction means in plain words
Isoflurane and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Primaquine belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check the preoperative QTc and correct potassium and magnesium. Monitor the ECG during anesthesia and avoid other QT-prolonging agents where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Primaquine?
MediHelp rates the interaction as moderate. Isoflurane and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval and primaquine may add to this effect. The risk is greatest during surgery when electrolyte disturbances and other QT-active drugs are common.
How serious is the interaction between Isoflurane and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the preoperative QTc and correct potassium and magnesium. Monitor the ECG during anesthesia and avoid other QT-prolonging agents where possible.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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