Drug interactions
Isoflurane + Propafenone
Severity: Moderate
Isoflurane and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval and depress cardiac conduction and contractility. With propafenone, which slows conduction and is negatively inotropic, there may be added risk of arrhythmia, hypotension or conduction block during anesthesia.
What this interaction means in plain words
Isoflurane and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Additive effects on cardiac conduction, repolarization and myocardial contractility.
What to do
Tell the anesthesia team about propafenone use before surgery. Monitor the ECG and hemodynamics continuously and maintain normal electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Propafenone?
MediHelp rates the interaction as moderate. Isoflurane and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval and depress cardiac conduction and contractility. With propafenone, which slows conduction and is negatively inotropic, there may be added risk of arrhythmia, hypotension or conduction block during anesthesia.
How serious is the interaction between Isoflurane and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about propafenone use before surgery. Monitor the ECG and hemodynamics continuously and maintain normal electrolytes.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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