Drug interactions
Isoflurane + Quetiapine
Severity: Moderate
Isoflurane and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval and quetiapine adds similar risk. Together they may increase the likelihood of ventricular arrhythmias during anesthesia.
What this interaction means in plain words
Isoflurane and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Review baseline QTc and correct electrolytes before surgery. Monitor the ECG perioperatively and have a plan for managing arrhythmias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Quetiapine?
MediHelp rates the interaction as moderate. Isoflurane and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval and quetiapine adds similar risk. Together they may increase the likelihood of ventricular arrhythmias during anesthesia.
How serious is the interaction between Isoflurane and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline QTc and correct electrolytes before surgery. Monitor the ECG perioperatively and have a plan for managing arrhythmias.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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