Drug interactions
Isoflurane + Quinidine
Severity: Moderate
Isoflurane and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval. Given together during anesthesia, they may raise the risk of torsades de pointes, especially with electrolyte disturbance. Quinidine may also potentiate neuromuscular blockade and cause hypotension.
What this interaction means in plain words
Isoflurane and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization through effects on potassium channels.
What to do
Review the baseline QTc and correct potassium and magnesium before anesthesia. Monitor the ECG continuously during surgery, and use neuromuscular monitoring if a blocker is given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Quinidine?
MediHelp rates the interaction as moderate. Isoflurane and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval. Given together during anesthesia, they may raise the risk of torsades de pointes, especially with electrolyte disturbance. Quinidine may also potentiate neuromuscular blockade and cause hypotension.
How serious is the interaction between Isoflurane and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the baseline QTc and correct potassium and magnesium before anesthesia. Monitor the ECG continuously during surgery, and use neuromuscular monitoring if a blocker is given.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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