Drug interactions
Isoflurane + Sertraline
Severity: Minor
Isoflurane and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval during anesthesia. Sertraline has a small QT effect, so the combined effect is probably minor in most patients.
What this interaction means in plain words
Isoflurane and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoflurane belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization causing QT prolongation.
What to do
Continue sertraline perioperatively and monitor the ECG during anesthesia. Maintain normal potassium and magnesium, especially if other QT-prolonging drugs are given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Sertraline?
MediHelp rates the interaction as minor. Isoflurane and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoflurane can prolong the QT interval during anesthesia. Sertraline has a small QT effect, so the combined effect is probably minor in most patients.
How serious is the interaction between Isoflurane and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue sertraline perioperatively and monitor the ECG during anesthesia. Maintain normal potassium and magnesium, especially if other QT-prolonging drugs are given.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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