Drug interactions
Isoflurane + Tetrabenazine
Severity: Moderate
Isoflurane and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine causes dose-related QT prolongation, and isoflurane may add to this effect. Tetrabenazine also causes sedation and can cause hypotension, which may compound anesthetic effects.
What this interaction means in plain words
Isoflurane and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive prolongation of ventricular repolarization (QTc) and additive CNS depression.
What to do
Check a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG and sedation depth during the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Isoflurane with Tetrabenazine?
MediHelp rates the interaction as moderate. Isoflurane and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetrabenazine causes dose-related QT prolongation, and isoflurane may add to this effect. Tetrabenazine also causes sedation and can cause hypotension, which may compound anesthetic effects.
How serious is the interaction between Isoflurane and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG and sedation depth during the procedure.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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