Drug interactions
Isoflurane + Vardenafil
Severity: Moderate
Isoflurane and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval and vardenafil has a modest QT effect, so perioperative use together may add to arrhythmia risk. Anesthetic vasodilation may also add to hypotension.
What this interaction means in plain words
Isoflurane and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation, with possible additive vasodilatory effects.
What to do
Inform the anesthesia team of recent vardenafil use and monitor ECG and blood pressure during surgery. Correct electrolyte abnormalities beforehand and avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Vardenafil?
MediHelp rates the interaction as moderate. Isoflurane and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval and vardenafil has a modest QT effect, so perioperative use together may add to arrhythmia risk. Anesthetic vasodilation may also add to hypotension.
How serious is the interaction between Isoflurane and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of recent vardenafil use and monitor ECG and blood pressure during surgery. Correct electrolyte abnormalities beforehand and avoid other QT-prolonging drugs where possible.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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