Drug interactions
Isoflurane + Voclosporin
Severity: Moderate
Isoflurane and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin has been associated with QT prolongation at supratherapeutic exposures, and isoflurane also lengthens the QT interval. The combined effect on repolarization may be additive, though the clinical significance at usual doses is probably small.
What this interaction means in plain words
Isoflurane and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Possible additive QT prolongation through delayed cardiac repolarization.
What to do
Review the baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG during the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Isoflurane with Voclosporin?
MediHelp rates the interaction as moderate. Isoflurane and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin has been associated with QT prolongation at supratherapeutic exposures, and isoflurane also lengthens the QT interval. The combined effect on repolarization may be additive, though the clinical significance at usual doses is probably small.
How serious is the interaction between Isoflurane and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG during the procedure.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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