Drug interactions
Isoflurane + Ziprasidone
Severity: Moderate
Isoflurane and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as isoflurane can prolong the QT interval, and ziprasidone has the same effect. During anesthesia the combination may increase the risk of torsades de pointes, particularly with electrolyte disturbance or bradycardia.
What this interaction means in plain words
Isoflurane and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Review the preoperative ECG, correct potassium and magnesium, and monitor the ECG continuously during anesthesia. Avoid other QT-prolonging drugs such as certain antiemetics in the perioperative period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Ziprasidone?
MediHelp rates the interaction as moderate. Isoflurane and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as isoflurane can prolong the QT interval, and ziprasidone has the same effect. During anesthesia the combination may increase the risk of torsades de pointes, particularly with electrolyte disturbance or bradycardia.
How serious is the interaction between Isoflurane and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the preoperative ECG, correct potassium and magnesium, and monitor the ECG continuously during anesthesia. Avoid other QT-prolonging drugs such as certain antiemetics in the perioperative period.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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