Drug interactions
Isoniazid + Liposomal doxorubicin
Severity: Moderate
Isoniazid and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has some CYP3A4 inhibitory activity and could modestly increase doxorubicin exposure. Both drugs can also be hepatotoxic, and reduced doxorubicin clearance in hepatic impairment may increase toxicity.
What this interaction means in plain words
Isoniazid and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Liposomal doxorubicin belongs to Oncology.
Why it happens
Possible CYP3A4 inhibition and overlapping hepatic effects.
What to do
Monitor liver function tests and blood counts. Reduce the doxorubicin dose if hepatic impairment or excess toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isoniazid and Liposomal doxorubicin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Isoniazid and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid has some CYP3A4 inhibitory activity and could modestly increase doxorubicin exposure. Both drugs can also be hepatotoxic, and reduced doxorubicin clearance in hepatic impairment may increase toxicity.
How serious is the interaction between Isoniazid and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and blood counts. Reduce the doxorubicin dose if hepatic impairment or excess toxicity develops.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
