Drug interactions
Isoniazid + Lomitapide
Severity: Major
Isoniazid and Lomitapide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a sensitive CYP3A4 substrate and elevated levels increase the risk of hepatotoxicity and gastrointestinal adverse effects. Isoniazid can inhibit CYP3A4, and lomitapide also carries hepatotoxicity risk by itself.
What this interaction means in plain words
Isoniazid and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isoniazid belongs to Anti Bacterial; Lomitapide belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 metabolism of lomitapide with potential additive hepatotoxicity.
What to do
Monitor liver enzymes closely and consider lomitapide dose reduction or an alternative lipid-lowering strategy during isoniazid treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Isoniazid
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Isoniazid with Lomitapide?
MediHelp rates the interaction as major. Isoniazid and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lomitapide is a sensitive CYP3A4 substrate and elevated levels increase the risk of hepatotoxicity and gastrointestinal adverse effects. Isoniazid can inhibit CYP3A4, and lomitapide also carries hepatotoxicity risk by itself.
How serious is the interaction between Isoniazid and Lomitapide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and consider lomitapide dose reduction or an alternative lipid-lowering strategy during isoniazid treatment.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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