Drug interactions
Isoniazid + Nisoldipine
Severity: Moderate
Isoniazid and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nisoldipine is highly dependent on intestinal and hepatic CYP3A4 for first-pass metabolism, so inhibitors can raise its levels substantially. Isoniazid is only a weak CYP3A4 inhibitor, so a clinically meaningful rise is possible but not certain. Possible effects are hypotension, flushing, headache and peripheral edema.
What this interaction means in plain words
Isoniazid and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Nisoldipine belongs to Cardiovascular.
Why it happens
Isoniazid weakly inhibits CYP3A4, decreasing first-pass metabolism of nisoldipine.
What to do
Monitor blood pressure and heart rate when isoniazid is started, and reduce the nisoldipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Isoniazid with Nisoldipine?
MediHelp rates the interaction as moderate. Isoniazid and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nisoldipine is highly dependent on intestinal and hepatic CYP3A4 for first-pass metabolism, so inhibitors can raise its levels substantially. Isoniazid is only a weak CYP3A4 inhibitor, so a clinically meaningful rise is possible but not certain. Possible effects are hypotension, flushing, headache and peripheral edema.
How serious is the interaction between Isoniazid and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when isoniazid is started, and reduce the nisoldipine dose if hypotension or edema develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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