Drug interactions
Isoniazid + Omeprazole
Severity: Minor
Isoniazid and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can inhibit CYP2C19 and may raise omeprazole concentrations. Clinical consequences are typically limited.
What this interaction means in plain words
Isoniazid and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Isoniazid inhibits CYP2C19 metabolism of omeprazole.
What to do
No routine adjustment is needed; be aware of possible increased PPI effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Omeprazole?
MediHelp rates the interaction as minor. Isoniazid and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid can inhibit CYP2C19 and may raise omeprazole concentrations. Clinical consequences are typically limited.
How serious is the interaction between Isoniazid and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; be aware of possible increased PPI effects.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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