Drug interactions
Isoniazid + Osilodrostat
Severity: Moderate
Isoniazid and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat is partly metabolized by CYP3A4, so inhibitors could increase its exposure and the risk of over-suppression of cortisol, hypotension and QT prolongation. Isoniazid is a weak-to-moderate inhibitor, so the effect is probably modest.
What this interaction means in plain words
Isoniazid and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Osilodrostat belongs to Endocrine.
Why it happens
Isoniazid inhibits CYP3A4, slightly reducing osilodrostat clearance.
What to do
Monitor cortisol levels, blood pressure, potassium and the QT interval. Adjust the osilodrostat dose according to the clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Osilodrostat
Frequently asked questions
Can I take Isoniazid with Osilodrostat?
MediHelp rates the interaction as moderate. Isoniazid and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat is partly metabolized by CYP3A4, so inhibitors could increase its exposure and the risk of over-suppression of cortisol, hypotension and QT prolongation. Isoniazid is a weak-to-moderate inhibitor, so the effect is probably modest.
How serious is the interaction between Isoniazid and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cortisol levels, blood pressure, potassium and the QT interval. Adjust the osilodrostat dose according to the clinical response.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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