Drug interactions
Isoniazid + Osimertinib
Severity: Minor
Isoniazid and Osimertinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib is partly metabolized by CYP3A4, but strong inhibitors have shown limited effect on its exposure. Isoniazid is a weak inhibitor, so a clinically important change is unlikely.
What this interaction means in plain words
Isoniazid and Osimertinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Osimertinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by isoniazid may slightly raise osimertinib concentrations.
What to do
No dose change is generally needed. Monitor for QTc prolongation, interstitial lung disease symptoms and liver tests as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Osimertinib
Frequently asked questions
Can I take Isoniazid with Osimertinib?
MediHelp rates the interaction as minor. Isoniazid and Osimertinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Osimertinib is partly metabolized by CYP3A4, but strong inhibitors have shown limited effect on its exposure. Isoniazid is a weak inhibitor, so a clinically important change is unlikely.
How serious is the interaction between Isoniazid and Osimertinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for QTc prolongation, interstitial lung disease symptoms and liver tests as usual.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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