Drug interactions
Isoniazid + Pomalidomide
Severity: Minor
Isoniazid and Pomalidomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is metabolized by CYP1A2 and CYP3A4, so inhibition could modestly increase its exposure. Isoniazid is a weak inhibitor of these enzymes and the clinical significance is unestablished.
What this interaction means in plain words
Isoniazid and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Pomalidomide belongs to Miscellaneous.
Why it happens
Possible weak inhibition of CYP3A4 and CYP1A2 by isoniazid may slightly reduce pomalidomide clearance.
What to do
No dose change is routinely needed. Monitor blood counts for neutropenia and thrombocytopenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Isoniazid with Pomalidomide?
MediHelp rates the interaction as minor. Isoniazid and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pomalidomide is metabolized by CYP1A2 and CYP3A4, so inhibition could modestly increase its exposure. Isoniazid is a weak inhibitor of these enzymes and the clinical significance is unestablished.
How serious is the interaction between Isoniazid and Pomalidomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor blood counts for neutropenia and thrombocytopenia.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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