Drug interactions
Isoniazid + Rimegepant
Severity: Minor
Isoniazid and Rimegepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rimegepant is a CYP3A4 substrate, and inhibitors of this enzyme raise its exposure. Isoniazid is only a weak to moderate CYP3A4 inhibitor, so the increase is expected to be modest. The clinical consequence is likely small because rimegepant is dosed as needed.
What this interaction means in plain words
Isoniazid and Rimegepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Rimegepant belongs to Central Nervous System.
Why it happens
Isoniazid may inhibit CYP3A4-mediated metabolism of rimegepant, modestly increasing its plasma concentrations.
What to do
No routine dose change is needed. Avoid a second rimegepant dose within 48 hours if a strong CYP3A4 inhibitor is also being given, and watch for increased adverse effects such as nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Rimegepant
Frequently asked questions
Can I take Isoniazid with Rimegepant?
MediHelp rates the interaction as minor. Isoniazid and Rimegepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rimegepant is a CYP3A4 substrate, and inhibitors of this enzyme raise its exposure. Isoniazid is only a weak to moderate CYP3A4 inhibitor, so the increase is expected to be modest. The clinical consequence is likely small because rimegepant is dosed as needed.
How serious is the interaction between Isoniazid and Rimegepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Avoid a second rimegepant dose within 48 hours if a strong CYP3A4 inhibitor is also being given, and watch for increased adverse effects such as nausea.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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