Drug interactions
Isoniazid + Ripretinib
Severity: Minor
Isoniazid and Ripretinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ripretinib is metabolized by CYP3A4, and strong inhibitors raise exposure to it and its active metabolite. Isoniazid is a weak inhibitor, so any increase is likely modest, though adverse reactions could be somewhat more frequent.
What this interaction means in plain words
Isoniazid and Ripretinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Ripretinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by isoniazid may modestly raise ripretinib exposure.
What to do
No empirical dose change is needed. Monitor for ripretinib adverse effects such as palmar-plantar erythrodysesthesia, hypertension and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Ripretinib
- Amobarbital + Ripretinib Major
- Apalutamide + Ripretinib Major
- Carbamazepine + Ripretinib Major
- Efavirenz + Ripretinib Major
- Enzalutamide + Ripretinib Major
- Phenytoin + Ripretinib Major
Frequently asked questions
Can I take Isoniazid with Ripretinib?
MediHelp rates the interaction as minor. Isoniazid and Ripretinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ripretinib is metabolized by CYP3A4, and strong inhibitors raise exposure to it and its active metabolite. Isoniazid is a weak inhibitor, so any increase is likely modest, though adverse reactions could be somewhat more frequent.
How serious is the interaction between Isoniazid and Ripretinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for ripretinib adverse effects such as palmar-plantar erythrodysesthesia, hypertension and fatigue.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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