Drug interactions
Isoniazid + Sonidegib
Severity: Moderate
Isoniazid and Sonidegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sonidegib is a CYP3A4 substrate whose exposure rises with strong inhibitors, increasing the risk of muscle toxicity. Isoniazid is a weak CYP3A inhibitor, so the effect is probably modest. Muscle-related adverse effects still warrant attention.
What this interaction means in plain words
Isoniazid and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Sonidegib belongs to Oncology.
Why it happens
Isoniazid may weakly inhibit CYP3A4, decreasing sonidegib clearance.
What to do
Monitor for muscle pain, weakness, and creatine kinase elevation. Consider an alternative or stop sonidegib if musculoskeletal toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Isoniazid with Sonidegib?
MediHelp rates the interaction as moderate. Isoniazid and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sonidegib is a CYP3A4 substrate whose exposure rises with strong inhibitors, increasing the risk of muscle toxicity. Isoniazid is a weak CYP3A inhibitor, so the effect is probably modest. Muscle-related adverse effects still warrant attention.
How serious is the interaction between Isoniazid and Sonidegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness, and creatine kinase elevation. Consider an alternative or stop sonidegib if musculoskeletal toxicity develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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