Drug interactions
Aprepitant + Sonidegib
Severity: Major
Aprepitant and Sonidegib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant may increase sonidegib exposure by inhibiting CYP3A4. This increases the risk of musculoskeletal toxicity such as myopathy and creatine kinase elevation.
What this interaction means in plain words
Aprepitant and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Sonidegib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated sonidegib metabolism by aprepitant.
What to do
Avoid the combination where possible. If aprepitant is needed, limit it to under 14 days and monitor for muscle symptoms and creatine kinase.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
- Chloramphenicol + Sonidegib Major
Frequently asked questions
Can I take Aprepitant with Sonidegib?
MediHelp rates the interaction as major. Aprepitant and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aprepitant may increase sonidegib exposure by inhibiting CYP3A4. This increases the risk of musculoskeletal toxicity such as myopathy and creatine kinase elevation.
How serious is the interaction between Aprepitant and Sonidegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If aprepitant is needed, limit it to under 14 days and monitor for muscle symptoms and creatine kinase.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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