Drug interactions
Amiodarone + Sonidegib
Severity: Major
Amiodarone and Sonidegib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may raise sonidegib exposure, increasing the risk of musculoskeletal toxicity such as myalgia and CK elevation, rhabdomyolysis.
What this interaction means in plain words
Amiodarone and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Sonidegib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism of sonidegib by amiodarone.
What to do
Avoid combination; if unavoidable, limit moderate CYP3A inhibitor use to under 14 days and monitor CK and muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Sonidegib
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
- Chloramphenicol + Sonidegib Major
Frequently asked questions
Can I take Amiodarone with Sonidegib?
MediHelp rates the interaction as major. Amiodarone and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone may raise sonidegib exposure, increasing the risk of musculoskeletal toxicity such as myalgia and CK elevation, rhabdomyolysis.
How serious is the interaction between Amiodarone and Sonidegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination; if unavoidable, limit moderate CYP3A inhibitor use to under 14 days and monitor CK and muscle symptoms.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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