Drug interactions
Bosentan + Sonidegib
Severity: Major
Bosentan and Sonidegib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce sonidegib exposure and thereby efficacy in basal cell carcinoma. Moderate CYP3A inducers have been shown to lower sonidegib levels.
What this interaction means in plain words
Bosentan and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Sonidegib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, increasing the metabolism of sonidegib.
What to do
Avoid the combination, as sonidegib labeling advises against moderate and strong CYP3A inducers. Use an alternative to bosentan where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Carbamazepine + Sonidegib Major
- Chloramphenicol + Sonidegib Major
Frequently asked questions
Can I take Bosentan with Sonidegib?
MediHelp rates the interaction as major. Bosentan and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan may reduce sonidegib exposure and thereby efficacy in basal cell carcinoma. Moderate CYP3A inducers have been shown to lower sonidegib levels.
How serious is the interaction between Bosentan and Sonidegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, as sonidegib labeling advises against moderate and strong CYP3A inducers. Use an alternative to bosentan where possible.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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