Drug interactions
Isoniazid + Tazemetostat
Severity: Moderate
Isoniazid and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a CYP3A substrate and moderate or strong inhibitors raise its exposure. Isoniazid is only weakly inhibitory, so a clinically significant rise is uncertain. Increased tazemetostat adverse effects are theoretically possible.
What this interaction means in plain words
Isoniazid and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Tazemetostat belongs to Miscellaneous.
Why it happens
Isoniazid may weakly inhibit CYP3A4, reducing tazemetostat metabolism.
What to do
Monitor for tazemetostat toxicity such as cytopenias and gastrointestinal effects. Reduce the dose per labeling if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Tazemetostat
Frequently asked questions
Can I take Isoniazid with Tazemetostat?
MediHelp rates the interaction as moderate. Isoniazid and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a CYP3A substrate and moderate or strong inhibitors raise its exposure. Isoniazid is only weakly inhibitory, so a clinically significant rise is uncertain. Increased tazemetostat adverse effects are theoretically possible.
How serious is the interaction between Isoniazid and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tazemetostat toxicity such as cytopenias and gastrointestinal effects. Reduce the dose per labeling if adverse effects emerge.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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