Drug interactions
Isoniazid + Vemurafenib
Severity: Moderate
Isoniazid and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib is a CYP3A4 substrate and both drugs can affect the liver. Isoniazid's weak CYP3A inhibition may modestly raise vemurafenib levels. The additive hepatotoxicity and QT concerns are more relevant than the pharmacokinetic effect.
What this interaction means in plain words
Isoniazid and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Vemurafenib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by isoniazid may raise vemurafenib levels, with additive hepatotoxicity.
What to do
Monitor liver enzymes and ECG with QT assessment during combined use. Reduce the vemurafenib dose per labeling if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Vemurafenib
Frequently asked questions
Can I take Isoniazid with Vemurafenib?
MediHelp rates the interaction as moderate. Isoniazid and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib is a CYP3A4 substrate and both drugs can affect the liver. Isoniazid's weak CYP3A inhibition may modestly raise vemurafenib levels. The additive hepatotoxicity and QT concerns are more relevant than the pharmacokinetic effect.
How serious is the interaction between Isoniazid and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and ECG with QT assessment during combined use. Reduce the vemurafenib dose per labeling if toxicity occurs.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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