Drug interactions
Isoniazid + Zolmitriptan
Severity: Minor
Isoniazid and Zolmitriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak monoamine oxidase inhibiting activity, and zolmitriptan is partly metabolised by MAO-A, so exposure may rise. Serotonin toxicity is theoretical and unlikely at usual doses.
What this interaction means in plain words
Isoniazid and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Zolmitriptan belongs to Central Nervous System.
Why it happens
Weak MAO inhibition by isoniazid may reduce zolmitriptan metabolism.
What to do
No routine change is needed; counsel the patient to report agitation, tremor, sweating or marked headache worsening and keep to the lowest effective zolmitriptan dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Isoniazid with Zolmitriptan?
MediHelp rates the interaction as minor. Isoniazid and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid has weak monoamine oxidase inhibiting activity, and zolmitriptan is partly metabolised by MAO-A, so exposure may rise. Serotonin toxicity is theoretical and unlikely at usual doses.
How serious is the interaction between Isoniazid and Zolmitriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel the patient to report agitation, tremor, sweating or marked headache worsening and keep to the lowest effective zolmitriptan dose.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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