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Drug interactions

Isoproterenol + Rasagiline

Severity: Moderate

Isoproterenol and Rasagiline: moderate interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Isoproterenol is a beta agonist metabolized mainly by COMT, with limited MAO involvement. MAO inhibition may modestly increase its cardiovascular effects such as tachycardia and blood pressure changes.

What this interaction means in plain words

Isoproterenol and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Isoproterenol belongs to Respiratory; Rasagiline belongs to Central Nervous System.

Evidence level: Low

Why it happens

Additive sympathomimetic effects, with possible reduced catecholamine metabolism.

What to do

Monitor heart rate, rhythm and blood pressure during isoproterenol use and titrate cautiously from low doses.

What to ask your pharmacist

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Isoproterenol with Rasagiline?

MediHelp rates the interaction as moderate. Isoproterenol and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol is a beta agonist metabolized mainly by COMT, with limited MAO involvement. MAO inhibition may modestly increase its cardiovascular effects such as tachycardia and blood pressure changes.

How serious is the interaction between Isoproterenol and Rasagiline?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure during isoproterenol use and titrate cautiously from low doses.

What other medicines interact with Rasagiline?

MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.

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