Drug interactions
Isoproterenol + Salbutamol
Severity: Moderate
Isoproterenol and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are beta-adrenergic agonists, so combining them produces additive tachycardia, hypertension or hypotension, tremor, arrhythmias and potassium lowering. The risk of cardiac adverse effects is increased, especially in patients with heart disease.
What this interaction means in plain words
Isoproterenol and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Salbutamol belongs to Respiratory.
Why it happens
Additive beta-adrenergic receptor stimulation, including beta-2 mediated intracellular potassium shift.
What to do
Avoid concurrent use where possible; if both are needed, monitor heart rate, rhythm, blood pressure and serum potassium closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isoproterenol and Salbutamol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Salbutamol
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Salbutamol?
MediHelp rates the interaction as moderate. Isoproterenol and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are beta-adrenergic agonists, so combining them produces additive tachycardia, hypertension or hypotension, tremor, arrhythmias and potassium lowering. The risk of cardiac adverse effects is increased, especially in patients with heart disease.
How serious is the interaction between Isoproterenol and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if both are needed, monitor heart rate, rhythm, blood pressure and serum potassium closely.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
