Drug interactions
Isosorbide dinitrate + Rifapentine
Severity: Minor
Isosorbide dinitrate and Rifapentine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is a CYP3A4 inducer that can lower levels of many drugs. Isosorbide dinitrate is cleared largely by non-CYP pathways, so a clinically important effect is unlikely.
What this interaction means in plain words
Isosorbide dinitrate and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isosorbide dinitrate belongs to Cardiovascular; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4, a minor pathway for isosorbide dinitrate.
What to do
No routine adjustment is needed. Monitor anginal symptoms and increase the nitrate dose only if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Isosorbide dinitrate with Rifapentine?
MediHelp rates the interaction as minor. Isosorbide dinitrate and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifapentine is a CYP3A4 inducer that can lower levels of many drugs. Isosorbide dinitrate is cleared largely by non-CYP pathways, so a clinically important effect is unlikely.
How serious is the interaction between Isosorbide dinitrate and Rifapentine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor anginal symptoms and increase the nitrate dose only if control is lost.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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