Drug interactions
Isosorbide mononitrate + Lenacapavir
Severity: Minor
Isosorbide mononitrate and Lenacapavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may increase exposure to CYP3A substrates. Isosorbide mononitrate is cleared mainly by denitration and glucuronidation rather than CYP3A4, so a clinically meaningful change is unlikely.
What this interaction means in plain words
Isosorbide mononitrate and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isosorbide mononitrate belongs to Cardiovascular; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, a minor pathway for mononitrate elimination.
What to do
No dose adjustment is required. Monitor for hypotension and headache when starting lenacapavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide mononitrate
- Avanafil + Isosorbide mononitrate Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Sildenafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide mononitrate Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Isosorbide mononitrate with Lenacapavir?
MediHelp rates the interaction as minor. Isosorbide mononitrate and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A inhibitor and may increase exposure to CYP3A substrates. Isosorbide mononitrate is cleared mainly by denitration and glucuronidation rather than CYP3A4, so a clinically meaningful change is unlikely.
How serious is the interaction between Isosorbide mononitrate and Lenacapavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for hypotension and headache when starting lenacapavir.
What other medicines interact with Isosorbide mononitrate?
MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide mononitrate page.
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