Drug interactions
Isradipine + Itraconazole
Severity: Major
Isradipine and Itraconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole inhibits CYP3A4 and can markedly raise isradipine concentrations, leading to hypotension, peripheral edema and tachycardia. Itraconazole also has negative inotropic effects, which may be additive with calcium channel blockers and worsen heart failure.
What this interaction means in plain words
Isradipine and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition reduces isradipine clearance, with additive negative inotropy.
What to do
Monitor blood pressure, heart rate and signs of heart failure, and reduce the isradipine dose or choose a different antihypertensive. Avoid in patients with heart failure or reduced ventricular function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Isradipine with Itraconazole?
MediHelp rates the interaction as major. Isradipine and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole inhibits CYP3A4 and can markedly raise isradipine concentrations, leading to hypotension, peripheral edema and tachycardia. Itraconazole also has negative inotropic effects, which may be additive with calcium channel blockers and worsen heart failure.
How serious is the interaction between Isradipine and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and signs of heart failure, and reduce the isradipine dose or choose a different antihypertensive. Avoid in patients with heart failure or reduced ventricular function.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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