Drug interactions
Isradipine + Labetalol
Severity: Moderate
Isradipine and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining labetalol with the dihydropyridine calcium channel blocker isradipine produces additive blood pressure lowering. This is often used deliberately, but it can cause excessive hypotension, dizziness and reflex or conduction effects, particularly at treatment start or after dose increases.
What this interaction means in plain words
Isradipine and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic antihypertensive effect from combined alpha/beta adrenergic blockade and L-type calcium channel blockade.
What to do
Monitor blood pressure and heart rate when starting or changing doses, and titrate each drug gradually. Reduce the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Isradipine with Labetalol?
MediHelp rates the interaction as moderate. Isradipine and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining labetalol with the dihydropyridine calcium channel blocker isradipine produces additive blood pressure lowering. This is often used deliberately, but it can cause excessive hypotension, dizziness and reflex or conduction effects, particularly at treatment start or after dose increases.
How serious is the interaction between Isradipine and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or changing doses, and titrate each drug gradually. Reduce the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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