Drug interactions
Isradipine + Lurasidone
Severity: Moderate
Isradipine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone has alpha-adrenergic blocking activity that can cause orthostatic hypotension, which may add to the blood pressure lowering of isradipine. Patients may experience dizziness, syncope or falls, especially at the start of therapy.
What this interaction means in plain words
Isradipine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive effects from antipsychotic alpha-1 blockade and calcium channel blockade.
What to do
Monitor blood pressure and orthostatic symptoms during initiation and dose changes, and reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Isradipine with Lurasidone?
MediHelp rates the interaction as moderate. Isradipine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone has alpha-adrenergic blocking activity that can cause orthostatic hypotension, which may add to the blood pressure lowering of isradipine. Patients may experience dizziness, syncope or falls, especially at the start of therapy.
How serious is the interaction between Isradipine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms during initiation and dose changes, and reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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