Drug interactions
Isradipine + Metoprolol
Severity: Moderate
Isradipine and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isradipine is a dihydropyridine calcium channel blocker, and combining it with metoprolol is generally well tolerated and often used on purpose. Additive blood pressure lowering can still cause hypotension, particularly at the start of treatment.
What this interaction means in plain words
Isradipine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effect from arterial vasodilation and beta-blockade.
What to do
Monitor blood pressure and heart rate after starting or adjusting either drug. Reduce the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isradipine and Metoprolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Isradipine with Metoprolol?
MediHelp rates the interaction as moderate. Isradipine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isradipine is a dihydropyridine calcium channel blocker, and combining it with metoprolol is generally well tolerated and often used on purpose. Additive blood pressure lowering can still cause hypotension, particularly at the start of treatment.
How serious is the interaction between Isradipine and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after starting or adjusting either drug. Reduce the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
