Drug interactions
Isradipine + Nitroglycerin
Severity: Moderate
Isradipine and Nitroglycerin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydropyridine calcium channel blockers such as isradipine can add to the blood pressure lowering of nitroglycerin. Orthostatic hypotension, dizziness and reflex tachycardia may occur.
What this interaction means in plain words
Isradipine and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from calcium channel blockade and nitrate-induced smooth muscle relaxation.
What to do
Monitor blood pressure and counsel patients to rise slowly. Adjust the dose of either drug if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitroglycerin
- Avanafil + Nitroglycerin Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Nitroglycerin + Sildenafil Contraindicated
- Nitroglycerin + Tadalafil Contraindicated
- Nitroglycerin + Vardenafil Contraindicated
- Dihydroergotamine intranasal + Nitroglycerin Major
Frequently asked questions
Can I take Isradipine with Nitroglycerin?
MediHelp rates the interaction as moderate. Isradipine and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydropyridine calcium channel blockers such as isradipine can add to the blood pressure lowering of nitroglycerin. Orthostatic hypotension, dizziness and reflex tachycardia may occur.
How serious is the interaction between Isradipine and Nitroglycerin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel patients to rise slowly. Adjust the dose of either drug if symptomatic hypotension occurs.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Nitroglycerin page.
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