Drug interactions
Isradipine + Tizanidine
Severity: Moderate
Isradipine and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isradipine is a dihydropyridine calcium channel blocker that lowers blood pressure. Tizanidine may add to this effect and cause hypotension or dizziness.
What this interaction means in plain words
Isradipine and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from arterial vasodilation and central alpha-2 agonism.
What to do
Monitor blood pressure after starting or increasing either drug. Reduce the dose if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Isradipine with Tizanidine?
MediHelp rates the interaction as moderate. Isradipine and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isradipine is a dihydropyridine calcium channel blocker that lowers blood pressure. Tizanidine may add to this effect and cause hypotension or dizziness.
How serious is the interaction between Isradipine and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or increasing either drug. Reduce the dose if orthostatic symptoms occur.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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