Drug interactions
Istradefylline + Metaxalone
Severity: Minor
Istradefylline and Metaxalone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses istradefylline inhibits CYP3A4 and can increase exposure to sensitive substrates. Metaxalone levels could therefore rise, increasing sedation and dizziness.
What this interaction means in plain words
Istradefylline and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Dose-dependent CYP3A4 inhibition by istradefylline reduces metaxalone metabolism.
What to do
Monitor for increased drowsiness, especially if istradefylline 40 mg daily is used, and lower the metaxalone dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Metaxalone?
MediHelp rates the interaction as minor. Istradefylline and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At higher doses istradefylline inhibits CYP3A4 and can increase exposure to sensitive substrates. Metaxalone levels could therefore rise, increasing sedation and dizziness.
How serious is the interaction between Istradefylline and Metaxalone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness, especially if istradefylline 40 mg daily is used, and lower the metaxalone dose if needed.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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