Drug interactions
Istradefylline + Mifepristone
Severity: Moderate
Istradefylline and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inhibitors raise istradefylline exposure, and mifepristone is such an inhibitor. At higher istradefylline doses it may also increase CYP3A4 substrate levels such as mifepristone. Adverse effects such as dyskinesia may be increased.
What this interaction means in plain words
Istradefylline and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of istradefylline, and high-dose istradefylline weakly inhibits CYP3A4.
What to do
Limit istradefylline to 20 mg/day and monitor for dyskinesia and other adverse effects. Monitor mifepristone adverse effects if istradefylline is used at higher doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Mifepristone?
MediHelp rates the interaction as moderate. Istradefylline and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inhibitors raise istradefylline exposure, and mifepristone is such an inhibitor. At higher istradefylline doses it may also increase CYP3A4 substrate levels such as mifepristone. Adverse effects such as dyskinesia may be increased.
How serious is the interaction between Istradefylline and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit istradefylline to 20 mg/day and monitor for dyskinesia and other adverse effects. Monitor mifepristone adverse effects if istradefylline is used at higher doses.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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