Drug interactions
Istradefylline + Nadolol
Severity: Moderate
Istradefylline and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses inhibits P-glycoprotein and can increase exposure to P-gp substrates such as nadolol. This may strengthen beta-blocking effects including bradycardia and hypotension.
What this interaction means in plain words
Istradefylline and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Nadolol belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux increases nadolol absorption and reduces its clearance.
What to do
Monitor heart rate and blood pressure after starting istradefylline. Reduce the nadolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Nadolol?
MediHelp rates the interaction as moderate. Istradefylline and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at higher doses inhibits P-glycoprotein and can increase exposure to P-gp substrates such as nadolol. This may strengthen beta-blocking effects including bradycardia and hypotension.
How serious is the interaction between Istradefylline and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting istradefylline. Reduce the nadolol dose if bradycardia or hypotension develops.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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