Drug interactions
Istradefylline + Nicardipine
Severity: Moderate
Istradefylline and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline raises exposure to CYP3A4 and P-glycoprotein substrates, which may increase nicardipine effects such as hypotension, dizziness and edema. This effect was not seen at 20 mg daily.
What this interaction means in plain words
Istradefylline and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Istradefylline at higher doses inhibits CYP3A4 and P-glycoprotein, reducing nicardipine clearance.
What to do
Monitor blood pressure and consider lowering the nicardipine dose when istradefylline 40 mg daily is used. Keep istradefylline at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Nicardipine?
MediHelp rates the interaction as moderate. Istradefylline and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg daily, istradefylline raises exposure to CYP3A4 and P-glycoprotein substrates, which may increase nicardipine effects such as hypotension, dizziness and edema. This effect was not seen at 20 mg daily.
How serious is the interaction between Istradefylline and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and consider lowering the nicardipine dose when istradefylline 40 mg daily is used. Keep istradefylline at the lowest effective dose.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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