Drug interactions
Istradefylline + Nimodipine
Severity: Moderate
Istradefylline and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline raises exposure to CYP3A4 substrates, which could increase nimodipine effects such as hypotension. This effect was not seen at 20 mg daily.
What this interaction means in plain words
Istradefylline and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Nimodipine belongs to Cardiovascular.
Why it happens
Dose-dependent CYP3A4 inhibition by istradefylline reduces nimodipine metabolism.
What to do
Monitor blood pressure, especially if the istradefylline dose is 40 mg daily. Consider reducing the nimodipine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Nimodipine?
MediHelp rates the interaction as moderate. Istradefylline and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg daily, istradefylline raises exposure to CYP3A4 substrates, which could increase nimodipine effects such as hypotension. This effect was not seen at 20 mg daily.
How serious is the interaction between Istradefylline and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially if the istradefylline dose is 40 mg daily. Consider reducing the nimodipine dose.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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