Drug interactions
Istradefylline + Paclitaxel
Severity: Minor
Istradefylline and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline weakly inhibits CYP3A4 and P-glycoprotein and may raise paclitaxel exposure. This effect is not expected at the 20 mg daily dose.
What this interaction means in plain words
Istradefylline and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Paclitaxel belongs to Oncology.
Why it happens
Istradefylline at higher doses inhibits CYP3A4 and P-glycoprotein.
What to do
Keep istradefylline at 20 mg daily if possible and monitor for paclitaxel toxicity such as neutropenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Paclitaxel?
MediHelp rates the interaction as minor. Istradefylline and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg daily, istradefylline weakly inhibits CYP3A4 and P-glycoprotein and may raise paclitaxel exposure. This effect is not expected at the 20 mg daily dose.
How serious is the interaction between Istradefylline and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep istradefylline at 20 mg daily if possible and monitor for paclitaxel toxicity such as neutropenia.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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