Drug interactions
Istradefylline + Regorafenib
Severity: Moderate
Istradefylline and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg/day, istradefylline inhibits CYP3A4 and may increase regorafenib exposure. This may increase hepatotoxicity, hypertension and skin toxicity.
What this interaction means in plain words
Istradefylline and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Regorafenib belongs to Oncology.
Why it happens
Istradefylline at higher doses inhibits CYP3A4 metabolism of regorafenib.
What to do
Keep istradefylline at 20 mg/day where possible and monitor liver tests and blood pressure. Reduce regorafenib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Regorafenib?
MediHelp rates the interaction as moderate. Istradefylline and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg/day, istradefylline inhibits CYP3A4 and may increase regorafenib exposure. This may increase hepatotoxicity, hypertension and skin toxicity.
How serious is the interaction between Istradefylline and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep istradefylline at 20 mg/day where possible and monitor liver tests and blood pressure. Reduce regorafenib dose if toxicity occurs.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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