Drug interactions
Istradefylline + Roflumilast
Severity: Minor
Istradefylline and Roflumilast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At the higher 40 mg daily dose, istradefylline weakly inhibits CYP3A4 and may raise roflumilast exposure modestly. The effect is not expected at 20 mg daily.
What this interaction means in plain words
Istradefylline and Roflumilast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Roflumilast belongs to Respiratory.
Why it happens
Istradefylline at 40 mg/day inhibits CYP3A4, slightly reducing roflumilast clearance.
What to do
No routine dose change is needed. Monitor for roflumilast adverse effects such as diarrhea, insomnia and weight loss if istradefylline 40 mg/day is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Istradefylline and Roflumilast, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Roflumilast
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Roflumilast?
MediHelp rates the interaction as minor. Istradefylline and Roflumilast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At the higher 40 mg daily dose, istradefylline weakly inhibits CYP3A4 and may raise roflumilast exposure modestly. The effect is not expected at 20 mg daily.
How serious is the interaction between Istradefylline and Roflumilast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for roflumilast adverse effects such as diarrhea, insomnia and weight loss if istradefylline 40 mg/day is used.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
