Drug interactions
Istradefylline + Saxagliptin-metformin
Severity: Minor
Istradefylline and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At the 40 mg dose, istradefylline inhibits CYP3A4 and P-glycoprotein and may raise saxagliptin concentrations. The effect is unlikely to be significant at 20 mg/day, and saxagliptin has a wide margin of safety.
What this interaction means in plain words
Istradefylline and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux, reducing saxagliptin clearance.
What to do
No routine adjustment is needed; monitor for saxagliptin adverse effects such as hypoglycemia when istradefylline 40 mg/day is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Istradefylline and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At the 40 mg dose, istradefylline inhibits CYP3A4 and P-glycoprotein and may raise saxagliptin concentrations. The effect is unlikely to be significant at 20 mg/day, and saxagliptin has a wide margin of safety.
How serious is the interaction between Istradefylline and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for saxagliptin adverse effects such as hypoglycemia when istradefylline 40 mg/day is used.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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