Drug interactions
Istradefylline + Secobarbital
Severity: Major
Istradefylline and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may substantially lower istradefylline levels through CYP3A4 induction, reducing its benefit in Parkinson disease OFF episodes.
What this interaction means in plain words
Istradefylline and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Istradefylline belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases istradefylline metabolism.
What to do
Avoid concomitant use and choose a non-inducing sedative. If unavoidable, monitor motor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Secobarbital?
MediHelp rates the interaction as major. Istradefylline and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital may substantially lower istradefylline levels through CYP3A4 induction, reducing its benefit in Parkinson disease OFF episodes.
How serious is the interaction between Istradefylline and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose a non-inducing sedative. If unavoidable, monitor motor response.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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