Drug interactions
Istradefylline + Tamsulosin
Severity: Minor
Istradefylline and Tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg/day istradefylline weakly inhibits CYP3A4 and may increase tamsulosin exposure. The clinical effect is likely small, with possible dizziness or low blood pressure.
What this interaction means in plain words
Istradefylline and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Tamsulosin belongs to Genitourinary.
Why it happens
Istradefylline at higher doses inhibits CYP3A4 metabolism of tamsulosin.
What to do
Monitor for orthostatic symptoms if the istradefylline dose is 40 mg/day. Lower the tamsulosin dose only if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Tamsulosin?
MediHelp rates the interaction as minor. Istradefylline and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg/day istradefylline weakly inhibits CYP3A4 and may increase tamsulosin exposure. The clinical effect is likely small, with possible dizziness or low blood pressure.
How serious is the interaction between Istradefylline and Tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic symptoms if the istradefylline dose is 40 mg/day. Lower the tamsulosin dose only if adverse effects appear.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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